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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective inhibitor of DOT1L is… Expand
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We identified the… Expand
Chromatin modifying enzymes as modulators of reprogramming
Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated… Expand
A New Group B Adenovirus Receptor Is Expressed at High Levels on Human Stem and Tumor Cells
ABSTRACT CD46 is used by human group B adenoviruses (Ads) as a high-affinity attachment receptor. Here we show evidence that several group B Ads utilize an additional receptor for infection of human… Expand
MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches
The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias. More than 80 different… Expand
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX… Expand
Human milk as a carrier of biochemical messages
Not only does breast milk provides an ideal nutrient composition for the newborn, but it also contains a variety of substances that may actively influence growth and development of the infant and… Expand
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.
The t(6;11)(q27;q23) is a recurrent chromosomal rearrangement that encodes the MLLAF6 fusion oncoprotein and is observed in patients with diverse hematologic malignancies. The presence of the… Expand
Targeting epigenetic programs in MLL-rearranged leukemias.
Rearrangements of the Mixed-Lineage Leukemia (MLL) gene are found in > 70% of infant leukemia, ~ 10% of adult acute myelogenous leukemia (AML), and many cases of secondary acute leukemias. The… Expand
A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases.
- P. Sova, Xiao-wei Ren, +4 authors A. Lieber
- Medicine, Biology
- Molecular therapy : the journal of the American…
- 1 April 2004
We have constructed a new capsid-modified adenovirus (Ad) vector that specifically replicates in tumor cells and expresses TNF-related apoptosis-inducing ligand (TRAIL). The Ad capsid contains… Expand