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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
).Although this may not be the only mecha-nism by which clozapine elicits its effects onPCP-induced cognitive dysfunction, thisactivation of the dopamine system of theprefrontal cortex may contributeExpand
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Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence.
To evaluate dorsolateral prefrontal cortex (DLPFC) physiology and function simultaneously, 20 medication-free patients with chronic schizophrenia and 25 normal controls underwent three separate xenonExpand
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Meta‐analysis of neuroimaging studies of the Wisconsin Card‐Sorting task and component processes
A quantitative meta‐analysis using the activation likelihood estimation (ALE) method was used to investigate the brain basis of the Wisconsin Card‐Sorting Task (WCST) and two hypothesized componentExpand
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Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study
To determine the neural circuitry engaged by performance of the Wisconsin Card Sorting Test (WCST), a neuropsychological test traditionally considered to be sensitive to prefrontal lesions, regionalExpand
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Variation in dopamine genes influences responsivity of the human reward system
In humans, dopamine neurotransmission is influenced by functional polymorphisms in the dopamine transporter (DAT1) and catechol-O-methyltransferase (COMT) genes. Here, we used event-relatedExpand
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Neural correlates of genetically abnormal social cognition in Williams syndrome
Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety.Expand
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Neural Basis of Genetically Determined Visuospatial Construction Deficit in Williams Syndrome
A unique opportunity to understand genetic determinants of cognition is offered by Williams syndrome (WS), a well-characterized hemideletion on chromosome 7q11.23 that causes extreme, specificExpand
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Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene forExpand
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Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET.
The PET H2 15O-bolus method was used to image regional brain activity in normal human subjects during intense pain induced by intradermal injection of capsaicin and during post-capsaicin mechanicalExpand
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H(2)(15)O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans.
Steady-state arterial spin tagging approaches can provide quantitative images of CBF, but have not been validated in humans. The work presented here compared CBF values measured using steady-stateExpand
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