• Publications
  • Influence
Potentially inappropriate prescribing and cost outcomes for older people: a national population study.
TLDR
A retrospective national population study on the prevalence of potentially inappropriate prescribing in a national Irish older population using European specific explicit prescribing criteria identifies a high prevalence of PIP in Ireland with significant cost consequences. Expand
Beta blockers and breast cancer mortality: a population- based study.
TLDR
Evidence in humans is provided to support preclinical observations suggesting that inhibiting the β₂-adrenergic signaling pathway can reduce breast cancer progression and mortality. Expand
Potentially inappropriate prescribing and adverse health outcomes in community dwelling older patients.
TLDR
Reducing PIP in primary care may help lower the burden of ADEs, its associated health care use and costs and enhance quality of life in older patients. Expand
Sputum Candida albicans presages FEV₁ decline and hospital-treated exacerbations in cystic fibrosis.
TLDR
Airway colonization with C albicans presaged a greater rate of FEV₁ decline and hospital-treated exacerbations in CF and was best predicted by pancreatic insufficiency, osteopenia, and cocolonization with Pseudomonas species. Expand
Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland Enhanced Prescribing Database
TLDR
The prevalence of PIP was high among the study cohort, increased with polypharmacy and was associated with significant cost, and the gross cost was estimated to be €6,098,419. Expand
The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.
TLDR
This study provides a rationale for the therapeutic effect of itraconazole and implied that the therapeutic potential of vitamin D supplementation in preventing ABPA is only feasible with concurrent elimination of A. fumigatus to permit VDR expression and its positive functional consequences. Expand
DYNAMO-HIA–A Dynamic Modeling Tool for Generic Health Impact Assessments
TLDR
DYNAMO-HIA (Dynamic Modeling for Health Impact Assessment) is a potential standard tool for health impact assessment based on epidemiologic evidence by combining modest data needs with general accessibility and user friendliness within the causal framework of HIA. Expand
Prospective study of falls and risk factors for falls in adults with advanced cancer.
TLDR
Fifty percent of adults with advanced cancer, regardless of age, will experience a fall associated with high risk of physical injury, and there is a compelling need to assess the efficacy of assessment and management of modifiable fall risk factors in patients withAdvanced cancer. Expand
Statins and risk of treated incident diabetes in a primary care population.
TLDR
An increased risk of new onset treated diabetes was found in those treated with statins showing significant duration and dose effect, excepting fluvastatin, which only demonstrated a duration effect. Expand
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