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Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation.
The main disadvantages of peptide pharmaceuticals are their rapid degradation and excretion, their low hydrophilicity, and low shelf lifes. These bottlenecks can be circumvented by acylation withExpand
Peptide chemistry toolbox - Transforming natural peptides into peptide therapeutics.
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became anExpand
Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act Distributively*
Asymmetric dimethylation of arginine residues is a common posttranslational modification of proteins carried out by type I protein arginine methyltransferases, including PRMT1 and -3. We report thatExpand
Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.
Neurotensin (NT) is a peptide expressed in the brain and in the gastrointestinal tract. Brain NT inhibits food intake, but the effects of peripheral NT are less investigated. In this study,Expand
Peptides and peptide conjugates: therapeutics on the upward path.
The main benefit of natural peptides, peptide analogs and newly designed peptides as therapeutics, lies in their high selectivity and affinity, which are frequently in the nanomolar range. New drugsExpand
Peptide drugs to target G protein-coupled receptors.
Major indications for use of peptide-based therapeutics include endocrine functions (especially diabetes mellitus and obesity), infectious diseases, and cancer. Whereas some peptide pharmaceuticalsExpand
Peptide modifications differentially alter G protein-coupled receptor internalization and signaling bias.
Although G protein-coupled receptors (GPCRs) are targeted by more clinically used drugs than any other type of protein, their ligand development is particularly challenging. Humans have fourExpand
Position and Length of Fatty Acids Strongly Affect Receptor Selectivity Pattern of Human Pancreatic Polypeptide Analogues
Pancreatic polypeptide (PP) is a satiety‐inducing gut hormone targeting predominantly the Y4 receptor within the neuropeptide Y multiligand/multireceptor family. Palmitoylated PP‐based ligands haveExpand
Palmitoylated SDF1 α Shows Increased Resistance against Proteolytic Degradation in Liver Homogenates
The chemokine stromal cell‐derived factor‐1 α (SDF1 α) is strongly involved in organogenesis, as well as inflammation and tissue repair, and acts by attracting different kinds of stem and progenitorExpand
Selective labelling of stromal cell‐derived factor 1α with carboxyfluorescein to study receptor internalisation
SDF1α plays an important role in the regeneration of injured tissue after ischemia or stroke by inducing the migration of progenitor cells. In order to study the function of this therapeuticallyExpand