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Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
The similarities of the growth defects caused by mutations in chico and the insulin receptor gene in Drosophila and by perturbations of the insulin/IGF1 signaling pathway in vertebrates suggest that this pathway plays a conserved role in the regulation of overall growth by controling cell size, cell number, and metabolism. Expand
Calmodulin Regulation of Drosophila Light-Activated Channels and Receptor Function Mediates Termination of the Light Response In Vivo
The results show that CAM coordinates termination of the light response by modulating receptor and ion channel activity, and the importance of calmodulin in mediating calcium-dependent negative regulation of phototransduction is demonstrated. Expand
Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance KCa Channel,IKCa1 *
The results suggest that Ca2+-calmodulin-induced conformational changes in all four subunits are necessary for the channel to open. Expand
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
Using spectroscopic, enzyme kinetic and surface plasmon resonance spectroscopy analyses, it is shown that low Ca2+ concentrations increase the affinity of CaM for EF and CyaA causing their activation, but higher Ca2- concentrations directly inhibit catalysis. Expand
The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus
This role of Spag4 in centriolar attachment does not involve either of the two KASH proteins of the Drosophila genome (Klarsicht and MSP-300), but does require the coiled-coil protein Yuri Gagarin. Expand
Ca2+ binding and conformational change in two series of point mutations to the individual Ca(2+)-binding sites of calmodulin.
Two series of site-directed mutations to the individual Ca(2+)-binding sites of Drosophila melanogaster calmodulin have been generated and studied and it appears that binding of Ca2+ to either carboxyl-terminal site can elicit the first phase of the response but the second phase is almost abolished when site 4 is the mutated site. Expand
Drosophila melanogaster--the model organism of choice for the complex biology of multi-cellular organisms.
An overview of the genetic methodologies available in Drosophila is given, together with examples of outstanding recent contributions to the understanding of cell and organismal biology, and the growing contribution of Drosophile to the authors' knowledge of gravity-related responses is addressed. Expand
bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery*.
Findings suggest that repression of nanos mRNA translation occurs on the ribosome and involves a role for beta NAC, a subunit of Nascent polypeptide Associated Complex (NAC). Expand
Gravitaxis in Drosophila melanogaster: a forward genetic screen
A forward genetic screen using Drosophila melanogaster that provides insight into these characteristics is described here and 18 candidate genes are now implicated in the gravitaxic behavior of flies. Expand
Single-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in Drosophila.
The ability of near-infrared fluorescence imaging to detect single-walled carbon nanotubes (SWNTs) in organisms and biological tissues has been explored using Drosophila melanogaster (fruit flies).Expand