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ASVCP reference interval guidelines: determination of de novo reference intervals in veterinary species and other related topics.
TLDR
This report is a condensation of the ASVCP 2011 consensus guidelines for determination of de novo RI in veterinary species, which mirror the 2008 Clinical Laboratory and Standards Institute recommendations, but with language and examples specific to veterinary species. Expand
Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer
TLDR
Interestingly, it is found that other classes of HERV env mRNAs, including ERV3 and HERV‐E, are expressed in the same ovarian cancer tissues that expressed HerV‐K, and anti‐HERV antibodies including anti‐ERV3, anti‐herVE and anti-HERVE were detected in patients with ovarian cancer, but not in normal female controls. Expand
Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus).
TLDR
Among 585 sentinel ICR mice (Mus musculus), 8 had unusual microscopic lesions in the kidney that were considered degenerative changes, possibly due to a toxic insult, and general health monitoring was negative for pathogens. Expand
Preclinical Mammalian Safety Studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA)
TLDR
Results demonstrate that EPHARNA is well tolerated at all doses tested, which has led to an ongoing first-in-human phase I clinical trial (NCT01591356) and previously published in vivo validation studies. Expand
A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys
TLDR
Evaluated ligand-directed peptidomimetic CKGGRAKDC-GG-D(KLAKLAK)2 (henceforth termed adipotide) in obese Old World monkeys resulted in a reduction in body mass, an improvement in insulin resistance, and a decrease in abdominal circumference, key predictors of diabetes in humans. Expand
Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice‐site mutation in a family of Norfolk terrier dogs
TLDR
This data indicates that spontaneous keratin mutations in suprabasal epidermal keratins 1 and 10 have not been confirmed in a species other than human, and these mutations may be responsible for hyperkeratosis in humans. Expand
Morphologic, immunohistochemical, and molecular characterization of hepatosplenic T-cell lymphoma in a dog.
TLDR
A 13-year-old neutered male Jack Russell Terrier was presented to the Texas Veterinary Medical Center with a history of lethargy, depression, vomiting, and fever, and malignant round cell neoplasia and marked extramedullary hematopoiesis were diagnosed on aspirates of the spleen. Expand
Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
TLDR
These mouse mutations constitute a suitable model for both mechanistic and preclinical studies of CTLN1 and other hyperammonemic encephalopathies and underscore the importance of complementing knockout mutations with hypomorphic mutations for the generation of animal models of human genetic diseases. Expand
Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study
TLDR
The authors have worked systematically to map human endothelial receptors (“vascular zip codes”) within tumors through direct peptide library selection in cancer patients through directly selecting a ligand‐binding motif to the interleukin‐11 receptor alpha (IL‐11Rα) in the human vasculature. Expand
Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates
TLDR
The membrane-associated glucose response protein 78 (GRP78) is investigated as a therapeutic target in leukemia and lymphoma and the efficacy of the GRP78-targeted proapoptotic drug bone metastasis targeting peptidomimetic 78 (BMTP-78), a member of the D(KLAKLAK)2-containing class of agents is evaluated. Expand
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