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Human DJ-1 and its homologs are novel glyoxalases.
TLDR
It is reported here that human DJ-1 and its homologs of the mouse and Caenorhabditis elegans are novel types of glyoxalase, converting Glyoxal or methylglyoxal to glycolic or lactic acid, respectively, in the absence of glutathione.
Novel glyoxalases from Arabidopsis thaliana
TLDR
Six Arabidopsis thaliana genes from the DJ‐1/PfpI superfamily are examined for similarity to the recently characterized bacterial and animal glyoxalases andDJ‐1d differs from its animal and bacterial homologs with respect to the configuration of its catalytic residues and the oligomeric property of the enzyme.
Regulation of vascular endothelial growth factor signaling by miR-200b
TLDR
It is shown that transfection of synthetic miR-200b reduced protein levels of VEGF, Flt-1, and KDR, and that miR -200b may have therapeutic potential as an angiogenesis inhibitor.
Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.
TLDR
An imaging method that allows simultaneous in situ quantification of cholesterol in two leaflets of the plasma membrane (PM) using tunable orthogonal cholesterol sensors found excellent correlation between the IPM cholesterol level and cellular Wnt signaling activity, suggesting that TAPMC and stimulus-induced PM cholesterol redistribution are crucial for tight regulation of cellular processes under physiological conditions.
Novel Mechanism of Massive Photoreceptor Degeneration Caused by Mutations in the trp Gene of Drosophila
  • Jaeseung Yoon, H. C. Ben-Ami, W. Pak
  • Biology
    The Journal of Neuroscience
  • 15 January 2000
TLDR
Evidence is provided for a specific mechanism for massive degeneration of photoreceptors in Drosophila and as some human homologs of TRP are highly expressed in the brain, a similar mechanism could be a major contributor to degenerative disorders of the brain.
Transactivation of the mouse sulfonylurea receptor I gene by BETA2/NeuroD.
TLDR
The results indicate that BETA2/NeuroD induces tissue-specific expression of the SUR1 gene through the E3 element, and the stimulatory effect of ngn3 in HIT Cells may require factors specifically expressed in HIT cells.
Single Amino Acid Change in the Fifth Transmembrane Segment of the TRP Ca2+ Channel Causes Massive Degeneration of Photoreceptors*
TLDR
It is shown that a single amino acid change, Phe-550 to Ile, near the beginning of the fifth transmembrane domain of TRP channel subunits is necessary to induce, and sufficient to closely mimic, the original mutant phenotypes of TrpP365.
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