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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptiveExpand
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Predicting Inhibitory Drug—Drug Interactions and Evaluating Drug Interaction Reports Using Inhibition Constants
OBJECTIVE: To review the use of inhibitory constants (Ki) determined from in vitro experiments in the prediction of the significance of inhibitory drug—drug interactions (DDIs). DATA SOURCES:Expand
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The influence of anesthetic agents on rat hepatic cytochromes P450 in vivo.
The objective of this study was to identify which anesthetics when used acutely will affect cytochrome P450 (CYP) activity in male Sprague-Dawley rats in vivo. The anesthetics tested were fentanylExpand
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Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats.
A dose-response curve for the hypoprothrombinemic effect of brodifacoum 3-[-3(4'-bromobiphenyl-4-yl) 1,2,3,4-tetrahydronaphth-1-yl] -4-hydroxycoumarin, was constructed using doses ranging from 0.1 toExpand
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PXR and the regulation of apoA1 and HDL-cholesterol in rodents.
Orphan nuclear receptors (ONRs) have been implicated in the regulation of lipids. Several clinical studies conducted either prospectively or epidemiologically have pointed to a link between theExpand
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Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes
1. Cryopreserved human hepatocytes were used to predict in vivo hepatic clearance (CL hepatic) from estimates of in vitro intrinsic clearance (). 2. was estimated for phenytoin, valproic acid,Expand
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Cyclooxygenase‐2 inhibition by rofecoxib reverses naturally occurring fever in humans
Cyclooxygenase (COX) exists as constitutive (COX‐1) and inducible (COX‐2) isoforms. Nonsteroidal anti‐inflammatory drugs (NSAIDs) such as ibuprofen and diclofenac inhibit both COX‐1 and COX‐2. TheExpand
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Differential Kinetics of Phenytoin in Elderly Patients
The elderly have a relatively high risk of developing adverse drug reactions. Phenytoin continues to be a preferred drug for treating generalised tonic-clonic seizures in the elderly and simpleExpand
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The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions.
We show that the current state of the art in predicting human PK and drug-drug interactions for NCEs solely from in vitro experiments has a high percentage of useful predictions. Expand
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