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Dose of midazolam should be reduced during diltiazem and verapamil treatments.
TLDR
If the administration of midazolam cannot be avoided, the dose of midAZolam should be reduced during concomitant treatment with diltiazem and verapamil, as these changes in the pharmacokinetics were associated with profound and prolonged sedative effects.
A potentially hazardous interaction between erythromycin and midazolam.
TLDR
Metabolism of both erythromycin and midazolam by the same cytochrome P450IIIA isozyme may explain the observed pharmacokinetic interaction.
A survey of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland
TLDR
Although there are several uncontrolled confounding factors, the overrepresentation of phenothiazines, especially thioridazine, among psychiatric patients who died suddenly is striking and, taken together with their well‐established arrhythmogenic effects, warrants further attention.
Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study.
TLDR
It is suggested that ethanol-induced suppression of nocturnal melatonin secretion and an increase in noradrenergic activity may be closely associated with disturbances in sleep and performance.
Itraconazole moderately increases serum concentrations of oxybutynin but does not affect those of the active metabolite
TLDR
Itraconazole moderately increases serum concentrations of oxybutynin, probably by inhibiting the CYP3A-mediated metabolism, however, the concentrations of N-desethyloxy butynin were practically unchanged.
Diazepam effects on the performance of healthy subjects are not enhanced by treatment with the antihistamine ebastine.
TLDR
Ebastine did not affect performance objectively or subjectively, yet borderline drowsiness was recorded during the first 3 h, and DZ produced impaired performance in various objective tests, and drowsness, weakness, clumsiness, mental slowness and poor performance were reported on visual analogue scales.
A pharmacokinetic interaction between roxithromycin and midazolam
TLDR
The interaction between roxithromycin and midazolam appears less likely to be clinically significant and only minor differences were seen between the treatments in one of the measured psychomotor parameters.
Effects of psychotropic drugs on digit substitution: comparison of the computerized symbol-digit substitution and traditional digit-symbol substitution tests
TLDR
The results suggest that manual dexterity in these computerized tests might contribute significantly to the total impairment of performance in response to different drugs.
A potentially hazardous interaction between erythromycin and midazolam
TLDR
Metabolism of both erythromycin and midazolam by the same cytochrome P450IIIA isozyme may explain the observed pharmacokinetic interaction.
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