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Hypermutability of CpG dinucleotides in the propeptide-encoding sequence of the human albumin gene.
An electrophoretically slow albumin variant was detected with a phenotype frequency of about 1:1000 in Sweden and was also found in a family of Scottish descent from Kaikoura, New Zealand, and inExpand
Point substitutions in albumin genetic variants from Asia.
It is suggested that some alloalbumins with the same substitution may have originated by independent mutations in various populations, and the apparent clustering of point substitutions in the protein structure may reflect hypermutability of the albumin gene. Expand
Genetic variants of serum albumin in Americans and Japanese.
A collaborative search for albumin genetic variants (alloalbumins) was undertaken by cellulose acetate and agarose electrophoresis at pH 8.6 of the sera of patients at two major medical centers in the United States and of nearly 20,000 blood donors in Japan, and seven different alloalbumin types were characterized by structural study. Expand
Point substitutions in Japanese alloalbumins.
The structural study of five rare types of inherited albumin variants discovered in the Biochemical Genetics Study of 15,581 unrelated children in Hiroshima and Nagasaki suggests that point substitutions are grouped in certain segments of the albumin molecule. Expand
Amino acid substitutions in albumin variants found in Brazil.
Conventional horizontal starch-gel electrophoresis in four buffer systems and structural studies were performed on four albumin variants, and the findings were compared with similar previous data, indicating hypermutability in some of its segments. Expand
Identical structural changes in inherited albumin variants from different populations.
This study has identified the amino acid substitution characteristic of albumin B in alloalbumins from six unrelated individuals of five different European descents and also in two Japanese and one Cambodian individuals, providing evidence for independent mutations at single sites in the albumin genome. Expand
The same substitution, glutamic acid----lysine at position 501, occurs in three alloalbumins of Asiatic origin: albumins Vancouver, Birmingham, and Adana.
An amino acid substitution in three alloalbumins of Asiatic origin is determined, and the same amino acid exchange occurs in albumins Vancouver and Birmingham, both from families that migrated from northern India, and in albumin Adana from Turkey. Expand
Single amino acid substitutions insn-glycerol-3-phosphate dehydrogenase allozymes fromDrosophila virilis
The amino acid sequence was compared among the three allelic variants (allozymes) ofsn-glycerol-3-phosphate dehydrogenase inD. virilis, which are detected by one-dimensional electrophoresis. TheExpand
Isolation and characterization of an adenylate kinase from the lateral muscle of bastard halibut Paralichthys olivaceus
Adenylate kinase (ATP:AMP phosphotransferase, EC (AK) is the enzyme that catalyzes the reversible conversion of MgATP + AMP to MgADP + ADP, a principal step in adenine nucleotide metabolismExpand