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Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice.
- K. Amirshahrokhi
- International immunopharmacology
- 1 October 2013
Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and… Expand
Methadone ameliorates multiple-low-dose streptozotocin-induced type 1 diabetes in mice.
- K. Amirshahrokhi, A. Dehpour, J. Hadjati, M. Sotoudeh, M. Ghazi-Khansari
- Toxicology and applied pharmacology
- 1 October 2008
Type 1 diabetes is an autoimmune disease characterized by inflammation of pancreatic islets and destruction of beta cells by the immune system. Opioids have been shown to modulate a number of immune… Expand
Effect of Methylsulfonylmethane on Paraquat-Induced Acute Lung and Liver Injury in Mice
Methylsulfonylmethane (MSM) is a natural organosulfur compound that exhibits antioxidative and anti-inflammatory effects. This study was carried out to investigate the effect of MSM on paraquat… Expand
Effect of Methylsulfonylmethane Pretreatment on Aceta-minophen Induced Hepatotoxicity in Rats
- S. Bohlooli, S. Mohammadi, +4 authors M. M. Chinifroush
- Iranian journal of basic medical sciences
- 1 August 2013
Objective(s): Methylsulfonylmethane (MSM) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains and beverages. In this study the effect of MSM… Expand
Thalidomide Ameliorates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation in an Experimental Model
ABSTRACTCisplatin is a platinum-based chemotherapy drug. However, its chemotherapeutic use is restricted by serious side effects, especially nephrotoxicity. Inflammatory mechanisms have a significant… Expand
The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: involvement of inflammatory cytokines and nitric oxide.
Excessive ethanol ingestion causes gastric mucosal damage through the inflammatory and oxidative processes. The present study was aimed to evaluate the protective effect of thalidomide on… Expand
The effect of methylsulfonylmethane on the experimental colitis in the rat.
- K. Amirshahrokhi, S. Bohlooli, M. M. Chinifroush
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 15 June 2011
Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a… Expand
Gastroprotective effect of 2-mercaptoethane sulfonate against acute gastric mucosal damage induced by ethanol.
Gastric mucosal damage induced by ethanol is a serious medical problem. Recent evidences suggest that reactive oxygen species and inflammatory mediators play a key role in the destruction of gastric… Expand
Carvedilol attenuates paraquat-induced lung injury by inhibition of proinflammatory cytokines, chemokine MCP-1, NF-κB activation and oxidative stress mediators.
Paraquat is a highly toxic herbicide that selectively accumulates in the lungs and causes pulmonary damage through the oxidative and inflammatory processes. Carvedilol is a nonselective beta and… Expand
Effect of captopril on TNF-α and IL-10 in the livers of bile duct ligated rats.
- K. Amirshahrokhi, M. Ghazi-Khansari, A. Mohammadi-Farani, Golnar Karimian
- Iranian journal of immunology : IJI
- 1 December 2010
BACKGROUND The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensin-converting enzyme (ACE) inhibitors provides some… Expand