Exhaled and nasal nitric oxide measurements : recommendations
This document was prepared following a Satellite Meeting of the European Respiratory Society Annual Scientific Meeting, held in Stockholm on 9 September, 1996, and attended by members of the ERS Taskforce on Measurement of Mediators in Exhaled Air.
Intragastric nitric oxide production in humans: measurements in expelled air.
High values of nitric oxide in expelled air from the stomach were shown in humans by chemiluminescence technique and this source of NO may be of importance for the integrity of the gastric mucosa in health and disease.
Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force.
High nitric oxide production in human paranasal sinuses
It is reported that NO in humans is produced by epithelial cells in the paranasal sinuses and is present in sinus air in very high concentrations, close to the highest permissible atmospheric pollution levels.
Increased amount of nitric oxide in exhaled air of asthmatics.
Exhaled NO may be used to instantly monitor ongoing bronchial inflammation, at least when involving inducible NO synthase, since increased production of NO in the lower airways may involve activated macrophages or neutrophils.
Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome.
- J. Lundberg, E. Weitzberg, S. Nordvall, R. Kuylenstierna, J. Lundberg, K. Alving
- MedicineEuropean Respiratory Journal
- 1 August 1994
The results clearly show that all NO in exhaled air of healthy subjects originates from the upper respiratory tract, with only a minor contribution from the lower airways, and the absence of nasal NO in children with Kartagener's syndrome could be of use as a simple noninvasive diagnostic test.
Greatly increased luminal nitric oxide in ulcerative colitis
Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation.
- A. Modin, H. Björne, M. Herulf, K. Alving, E. Weitzberg, J. Lundberg
- BiologyActa Physiologica Scandinavica
Study of the effects of physiological amounts of nitrite on NO generation and relaxation of rat aorta in vitro in a situation where environmental pH was reduced to levels seen in tissues during hypoxia/ischaemia illustrates non-enzymatic release of NO from nitrite at physiological concentrations.
Exhaled carbon monoxide is not elevated in patients with asthma or cystic fibrosis
The fractional concentration of carbon monoxide in expired gas was not increased in any of the patient groups, while the fractional concentrations of nitric oxide in expire gas was significantly elevated in patients with steroid-naïve asthma and allergic rhinitis.
Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects.