Author pages are created from data sourced from our academic publisher partnerships and public sources.
Mesenchymal Stem Cell-Based Tissue Regeneration is Governed by Recipient T Lymphocyte via IFN-γ and TNF-α
Stem cell–based regenerative medicine is a promising approach in tissue reconstruction. Here we show that proinflammatory T cells inhibit the ability of exogenously added bone marrow mesenchymal stem… Expand
Mesenchymal Stem Cell Transplantation Reverses Multiorgan Dysfunction in Systemic Lupus Erythematosus Mice and Humans
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in… Expand
Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis.
Systemic infusion of bone marrow mesenchymal stem cells (BMMSCs) yields therapeutic benefit for a variety of autoimmune diseases, but the underlying mechanisms are poorly understood. Here we show… Expand
Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases.
OBJECTIVE Periodontal disease is an inflammatory disorder with widespread morbidities involving both oral and systemic health. The primary goal of periodontal treatment is the regeneration of the… Expand
Cell-Based Immunotherapy With Mesenchymal Stem Cells Cures Bisphosphonate-Related Osteonecrosis of the Jaw–like Disease in Mice
- T. Kikuiri, I. Kim, +8 authors S. Shi
- Journal of bone and mineral research : the…
- 29 January 2010
Patients on high‐dose bisphosphonate and immunosuppressive therapy have an increased risk of bisphosphonate‐related osteonecrosis of the jaw (BRONJ); despite the disease severity, its pathophysiology… Expand
Pharmacologic Stem Cell Based Intervention as a New Approach to Osteoporosis Treatment in Rodents
Background Osteoporosis is the most prevalent skeletal disorder, characterized by a low bone mineral density (BMD) and bone structural deterioration, leading to bone fragility fractures. Accelerated… Expand
Characterization of bone marrow derived mesenchymal stem cells in suspension
- K. Akiyama, Yong-Ouk You, +6 authors S. Shi
- Biology, Medicine
- Stem Cell Research & Therapy
- 19 October 2012
IntroductionBone marrow mesenchymal stem cells (BMMSCs) are a heterogeneous population of postnatal precursor cells with the capacity of adhering to culture dishes generating colony-forming… Expand
mTOR inhibition rescues osteopenia in mice with systemic sclerosis
- C. Chen, K. Akiyama, +6 authors S. Shi
- Biology, Medicine
- The Journal of experimental medicine
- 12 January 2015
Chen et al. show that treatment with rapamycin, a drug known to inhibit mTOR signaling, rescues low bone density in mice with systemic sclerosis.
SHED repair critical-size calvarial defects in mice.
OBJECTIVE Stem cells from human exfoliated deciduous teeth (SHED) are a population of highly proliferative postnatal stem cells capable of differentiating into odontoblasts, adipocytes, neural cells,… Expand
Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo.
Statin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is known to promote bone formation. However, it is not clear whether statin affects the differentiation of pulp cells. This study… Expand