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Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.
Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system.
This study elucidated the intracellular fate of transferrin-modified liposomes and succeeded in altering it by introducing the pH-sensitive fusogenic peptide, GALA (WEAALAEAlAEALAEHLAEalAEALEALAA).
Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors.
The design and evaluation of low molecular weight peptide-based severe acute respiratory syndrome (SARS) chymotrypsin-like protease (3CL) protease inhibitors are described, and X-ray crystallography provided insights into the protein-ligand interactions.
Galectin-3 (Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia
- M. Yamamoto-Sugitani, J. Kuroda, M. Taniwaki
- BiologyProceedings of the National Academy of Sciences
- 10 October 2011
Results demonstrate that leukemia microenvironment-specific Gal-3 expression supports molecular signaling pathways for disease maintenance in BM and resistance to therapy in CML and suggest that Gal- 3 may be a candidate therapeutic target to help overcome BMME-mediated therapeutic resistance.
Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies
Dual Role of an N-terminal Amyloidogenic Mutation in Apolipoprotein A-I
- E. Adachi, Hiroyuki Nakajima, H. Saito
- Biology, ChemistryThe Journal of Biological Chemistry
- 11 December 2012
The results indicate dual critical roles of the arginine residue at position 26 in apoA-IIowa: destabilization of the N-terminal helix bundle structure in full-length protein and enhancement of amyloid fibril formation by the N–83 fragment.
Genetic regulation mediated by thiamin pyrophosphate‐binding motif in Saccharomyces cerevisiae
The possibility that the induction of THI genes is triggered by the activation of the complex attributed to decrease in intracellular TDP and the elevated complex in the autoregulatory fashion further upregulates THi genes is discussed.
The extreme N‐terminal region of human apolipoprotein A‐I has a strong propensity to form amyloid fibrils
Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor.
Facilitated recruitment of Pdc2p, a yeast transcriptional activator, in response to thiamin starvation.
- K. Nosaka, Hiroyoshi Esaki, M. Onozuka, H. Konno, Y. Hattori, K. Akaji
- BiologyFEMS microbiology letters
- 1 May 2012
It is demonstrated that Pdc2p interacts with the upstream region of THI genes and PDC5, which can bind to PDC2p and is required for the expression of PDC4 and the target consensus DNA sequence of Thi2p has been deduced.