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Suppressive function of androgen receptor in bone resorption
TLDR
It is shown that inactivation of AR in mice using a Cre-loxP system-mediated gene-targeting technique caused bone loss in males but not in females, and results indicate that AR function is indispensable for male-type bone formation and remodeling.
Brain masculinization requires androgen receptor function.
TLDR
It is suggested that perinatal brain masculinization requires AR function and that expression of male-typical behaviors in adults is mediated by both AR-dependent and -independent androgen signaling.
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.
TLDR
Findings establish that VDR in osteoblasts is a negative regulator of bone mass control and plays a role in bone mass regulation.
Disruption of Nuclear Vitamin D Receptor Gene Causes Enhanced Thrombogenicity in Mice*
TLDR
It is demonstrated that activation of nuclear VDR elicits antithrombotic effects in vivo, and suggested that the VDR system may play a physiological role in the maintenance of antithROMbotic homeostasis.
Pitavastatin, an HMG-CoA Reductase Inhibitor, Exerts eNOS-Independent Protective Actions Against Angiotensin II–Induced Cardiovascular Remodeling and Renal Insufficiency
TLDR
Pitavastatin exerts eNOS-independent protective actions against Ang II–induced cardiovascular remodeling and renal insufficiency through inhibition of the TGF-β-Smad 2/3 signaling pathway by suppression of oxidative stress.
Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis*
TLDR
The results suggest that, in male mice, the androgen-AR system participates in normal cardiac growth and modulates cardiac adaptive hypertrophy and fibrosis during the process of cardiac remodeling under hypertrophic stress.
Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
TLDR
Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction.
Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice.
TLDR
The results demonstrate that Dox-induced cardiotoxicity is aggravated in male ARKO mice via exacerbation of mitochondrial damage and superoxide generation, leading to enhanced apoptosis of cardiomyocytes.
Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.
TLDR
It is suggested that HCII is potentially therapeutic against atherosclerosis without causing coagulatory disturbance and protects against thrombin-induced remodeling of an injured vascular wall by inhibitingThrombin action.
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