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The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo
Curcumin appears to constitute a potential agent for the prevention of cancer progression, or at least of the initial phase of metastasis, in prostate cancer.
Role of hypoxia-inducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes.
Hypoxia-induced MMP-3 expression is exclusively regulated by HIF-1alpha, and hypoxia -induced M MP-1 or IL-8 expression appears to have salvage pathways other than the Hif-1 alpha pathway.
Increased Extracellular Survivin in the Synovial Fluid of Rheumatoid Arthritis Patients: Fibroblast-like Synoviocytes as a Potential Source of Extracellular Survivin
Findings suggest that extracellular survivin may be produced from rheumatoid FLS and may play an important role in the destructive RA process.
Tumor necrosis factor-alpha induces vascular endothelial growth factor-C expression in rheumatoid synoviocytes.
Overexpression of VEGF-C in FLS by stimulation with TNF-alpha may play an important role in the progression of synovial inflammation and hyperplasia in RA by contributing to local lymphangiogenesis and angiogenesis.
Establishment and characterization of bortezomib-resistant U266 cell line: Constitutive activation of NF-κB-mediated cell signals and/or alterations of ubiquitylation-related genes reduce
The findings provide the basis for developing therapeutic strategies in bortezomib-resistant relapsed and refractory MM patients and identify genes related to ubiquitination that were differentially regulated in U266/velR.
Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide
It is demonstrated that Slug is overexpressed in RA ST and that suppression of Slug gene facilitates apoptosis of FLS by increasing Puma transactivation, which may represent a potential therapeutic target in RA.
SLC29A1 (ENT1) polymorphisms and outcome of complete remission in acute myeloid leukemia
The results suggest the contribution of SLC29A1 to cytotoxic effects of AraC is suggested, which could be a potential marker for the achievement of CR of cancers of white blood cells including AML.