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Comprehensive Characterization of Cancer Driver Genes and Mutations
This study reports a PanCancer and PanSoftware analysis spanning 9,423 tumor exomes (comprising all 33 of The Cancer Genome Atlas projects) and using 26 computational tools to catalog driver genes and mutations, identifying 299 driver genes with implications regarding their anatomical sites and cancer/cell types. Expand
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing
Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited mutations is not known.Expand
Germline and Somatic Mutations in Homologous Recombination Genes Predict Platinum Response and Survival in Ovarian, Fallopian Tube, and Peritoneal Carcinomas
Germline or somatic mutations in homologous recombination genes are present in almost one third of ovarian carcinomas, including both serous and nonserous histologies, and the similar rate of homology recombination mutations in nonserous carcinomas supports their inclusion in PARP inhibitor clinical trials. Expand
Oncogenic Signaling Pathways in The Cancer Genome Atlas
This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Expand
Characterization of vaginal flora and bacterial vaginosis in women who have sex with women.
Data support the hypothesis that sexual exchange of vaginal secretions is a possible mechanism for acquisition of bacterial vaginosis, and suggest that other risk factors for BV exist. Expand
Pathogenic Germline Variants in 10,389 Adult Cancers
The largest investigation of predisposition variants in cancer to date finds 853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types, informing future guidelines of variant classification and germline genetic testing in cancer. Expand
Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women.
The data suggest that the endometrial cavity is not sterile in most women undergoing hysterectomy and that the presence of low levels of bacteria in the uterus is not associated with significant inflammation. Expand
Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization.
In the setting of IVF-ET, prophylactic doxycycline had little effect on vaginal bacteria, and specific bacteria recovered from the embryo transfer catheter appear associated with a detrimental or beneficial effect or with no effect on live-birth rates. Expand
Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial Vaginosis
The microbiota of the human vagina can be highly dynamic, and women with recurrent BV initially respond to antibiotic treatment with steep declines in bacterial concentrations, but these bacteria later reemerge, suggesting that antibiotic resistance in these bacteria is not an important factor mediating BV recurrence. Expand
Maternal Stress is Associated With Bacterial Vaginosis in Human Pregnancy
High levels of chronic stress during pregnancy are associated with bacterial vaginosis, and the effect of chronic maternal stress is independent of the effects of other established sociodemographic and behavioral risk factors for BV. Expand