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A common MUC5B promoter polymorphism and pulmonary fibrosis.
The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot. Expand
MARCKS Protein Is a Key Molecule Regulating Mucin Secretion by Human Airway Epithelial Cells in Vitro *
  • Yuehua Li, Linda D. Martin, G. Spizz, K. Adler
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2 November 2001
Several novel intracellular targets for pharmacological intervention in disorders involving aberrant secretion of respiratory mucin are suggested and may relate to other lesions involving exocytosis of membrane-bound granules in various cells and tissues. Expand
Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro.
Both ROS and RNS can be measured in the same lysates from airway epithelial cells, and that both ROS andRNS are produced in these cells in response to different stimuli. Expand
Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression.
The results support the following pathway, whereby T NF-alpha enhances expression of ICAM-1 in NHBE cells: TNF-alpha --> TNF (NF)-RI --> PC-PLC --> DAG --> PKC --> (NF-kappaB?) --> ICam-1 mRNA --> IC AM-1 surface expression. Expand
Interactions of oxygen radicals with airway epithelium.
Reactive oxygen species (ROS) have been implicated in the pathogenesis of numerous disease processes and Respiratory epithelium may be intimately involved in defense against, and pathophysiologic changes invoked by, ROS. Expand
Effects of cigarette smoke on epithelial cells of the respiratory tract.
Early events in the response to cigarette smoke or its components may be critical, and certainly an understanding of these events may help to elucidate the pathogenetic mechanisms of many chronic respiratory diseases. Expand
Rat tracheal epithelial cell differentiation in vitro.
The ability to modulate RTE cell phenotypes in culture will facilitate future studies investigating molecular regulation of tracheal cell proliferation, differentiation, and function. Expand
Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators.
The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases, and molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleUKin-8 ( IL-8) are discussed. Expand
Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression.
Generation of an oxidative stress was critical to induction of the ROFA- or vanadium-induced effects on airway epithelial gene expression, cytokine production, and cytotoxicity. Expand