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Structural characterization of lipid A obtained from Pantoea agglomerans lipopolysaccharide.
Lipopolysaccharide isolated from Pantoea agglomerans showed higher priming and triggering activities for macrophages in terms of tumor necrosis factor production than other lipopolysaccharides. ToExpand
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Oxidation of primary amines to ketones
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Chemoenzymatic synthesis of neuraminic acid analogs structurally varied at C-5 and C-9 as potential inhibitors of the sialidase from influenza virus.
The 9-amino or 9-N-acyl-5-trifluoroacetyl methyl alpha-ketosides (1a-c) and their 2,3-didehydro analogs (2a-c) have been synthesized through Neu5Ac aldolase-catalyzed aldol reaction ofExpand
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INVERSION OF ENANTIOSELECTIVITY IN HYDROLYSIS OF 1,4-DIHYDROPYRIDINES BY POINT MUTATION OF LIPASE PS
Abstract Mutant of lipase PS replaced three amino acids by site-specific mutagenesis first showed the inversion of enantioselectivity and the solvent effect in hydrolysis of 1,4-dihydropyridines.
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Inhibition of Infection of T-Cells with Human Immunodeficiency Virus Type 1 by Dideoxynucleosides Conjugated with Oligopeptides
We conjugated nucleoside derivatives that have anti-HIV-1 activities with oligopeptides that should bind to the gp120 of the HIV-1 virion, and examined their anti-HIV-1 activities. These derivatesExpand
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Biological activities of chemically synthesized 2-keto-3-deoxyoctonic acid-(alpha 2----6)-D-glucosamine analogs of lipid A.
The mitogenicity, lethal toxicity, and Shwartzman reaction of three derivatives of chemically synthesized 2-keto-3-deoxyoctonic acid-linked 2,3-diacyloxyacylglucosamine-4-phosphate (KDO-GlcN-4-P)Expand
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Antitumor activity and biological effects of chemically synthesized monosaccharide analogues of lipid A in mice.
Five synthetic monosaccharide analogues of lipid A containing two 3-acyloxytetradecanoyl and a phosphoryl group at the C-2, -3 and -4 positions of the glucosamine skelton were synthesized. TheExpand
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