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Structural characterization of lipid A obtained from Pantoea agglomerans lipopolysaccharide.
- D. Tsukioka, T. Nishizawa, +4 authors Den'ichi Mizuno
- Chemistry, Medicine
- FEMS microbiology letters
- 1 April 1997
Lipopolysaccharide isolated from Pantoea agglomerans showed higher priming and triggering activities for macrophages in terms of tumor necrosis factor production than other lipopolysaccharides. To… Expand
Chemoenzymatic synthesis of neuraminic acid analogs structurally varied at C-5 and C-9 as potential inhibitors of the sialidase from influenza virus.
The 9-amino or 9-N-acyl-5-trifluoroacetyl methyl alpha-ketosides (1a-c) and their 2,3-didehydro analogs (2a-c) have been synthesized through Neu5Ac aldolase-catalyzed aldol reaction of… Expand
INVERSION OF ENANTIOSELECTIVITY IN HYDROLYSIS OF 1,4-DIHYDROPYRIDINES BY POINT MUTATION OF LIPASE PS
Abstract Mutant of lipase PS replaced three amino acids by site-specific mutagenesis first showed the inversion of enantioselectivity and the solvent effect in hydrolysis of 1,4-dihydropyridines.
Asymmetric reactions catalyzed by chiral metal complexes. 41. Highly efficient asymmetric hydrogenation of amino ketone derivatives leading to practical syntheses of (S)-propranolol and related…
Synthesis of Styrenes Through the Biocatalytic Decarboxylation of trans-Cinnamic Acids by Plant Cell Cultures.
Inhibition of Infection of T-Cells with Human Immunodeficiency Virus Type 1 by Dideoxynucleosides Conjugated with Oligopeptides
We conjugated nucleoside derivatives that have anti-HIV-1 activities with oligopeptides that should bind to the gp120 of the HIV-1 virion, and examined their anti-HIV-1 activities. These derivates… Expand
Asymmetric Synthesis of Optically Active 1,4‐Dihydropyridines as Calcium Antagonists
Biological activities of chemically synthesized 2-keto-3-deoxyoctonic acid-(alpha 2----6)-D-glucosamine analogs of lipid A.
- T. Shimizu, S. Akiyama, T. Masuzawa, Y. Yanagihara, S. Nakamoto, K. Achiwa
- Biology, Medicine
- Infection and immunity
- 1 September 1987
The mitogenicity, lethal toxicity, and Shwartzman reaction of three derivatives of chemically synthesized 2-keto-3-deoxyoctonic acid-linked 2,3-diacyloxyacylglucosamine-4-phosphate (KDO-GlcN-4-P)… Expand
Antitumor activity and biological effects of chemically synthesized monosaccharide analogues of lipid A in mice.
- T. Shimizu, S. Akiyama, +5 authors K. Achiwa
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 25 October 1985
Five synthetic monosaccharide analogues of lipid A containing two 3-acyloxytetradecanoyl and a phosphoryl group at the C-2, -3 and -4 positions of the glucosamine skelton were synthesized. The… Expand