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ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
We recently identified angiogenin (ANG) as a candidate susceptibility gene for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by adult-onset loss of motor neurons. WeExpand
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Crystal structure of the human angiotensin-converting enzyme–lisinopril complex
Angiotensin-converting enzyme (ACE) has a critical role in cardiovascular function by cleaving the carboxy terminal His-Leu dipeptide from angiotensin I to produce a potent vasopressor octapeptide,Expand
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The CCN family of proteins: structure–function relationships
The CCN proteins are key signalling and regulatory molecules involved in many vital biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound healing. How theseExpand
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Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1
SUPERANTIGENS stimulate T cells bearing particular T-cell receptor Vβ sequences1,2, so they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding of superantigensExpand
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Crystal Structures of Apo- and Holo-bovine α-Lactalbumin at 2.2-Å Resolution Reveal an Effect of Calcium on Inter-lobe Interactions*
High affinity binding of Ca2+to α-lactalbumin (LA) stabilizes the native structure and is required for the efficient generation of native protein with correct disulfide bonds from the reducedExpand
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Cwp84, a Surface-associated Cysteine Protease, Plays a Role in the Maturation of the Surface Layer of Clostridium difficile*
Clostridium difficile is a major and growing problem as a hospital-associated infection that can cause severe, recurrent diarrhea. The mechanism by which the bacterium colonizes the gut duringExpand
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Eosinophil Granule Proteins: Form and Function
Experimental and clinical data strongly support a role for the eosinophil in the pathogenesis of asthma, allergic and parasitic diseases, and hypereosinophilic syndromes, in addition to more recentlyExpand
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Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase.
BACKGROUND The regulation of milk lactose biosynthesis is highly dependent on the action of a specifier protein, alpha-lactalbumin (LA). Together with a glycosyltransferase, LA forms the enzymeExpand
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A family of killer toxins
The ADP‐ribosylating toxins (ADPRTs) are a family of toxins that catalyse the hydrolysis of NAD and the transfer of the ADP‐ribose moiety onto a target. This family includes many notorious killers,Expand
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Botulinum and tetanus neurotoxins: structure, function and therapeutic utility.
The toxic products of the anaerobic bacteria Clostridium botulinum, Clostridium butyricum, Clostridium barati and Clostridium tetani are the causative agents of botulism and tetanus. The ability ofExpand
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