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Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy.
TLDR
Administration of RG7155 to patients led to striking reductions of CSF-1R(+)CD163(+) macrophages in tumor tissues, which translated into clinical objective responses in diffuse-type giant cell tumor (Dt-GCT) patients.
CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study.
TLDR
The primary objective was to evaluate the safety and tolerability of emactuzumab, and to determine the maximum tolerated dose or optimal biological dose, in patients with Dt-GCT of the soft tissue.
Bombesin Antagonist–Based Radioligands for Translational Nuclear Imaging of Gastrin-Releasing Peptide Receptor–Positive Tumors
TLDR
The promising preclinical results warrant clinical translation of these probes for SPECT and PET of GRPr-positive tumors, and the chelators do influence the affinity, antagonistic potency, and pharmacokinetics of the conjugates.
Phase 1 study of RG7155, a novel anti-CSF1R antibody, in patients with locally advanced pigmented villonodular synovitis (PVNS).
TLDR
This dose-escalation and –extension phase I study treated patients with locally advanced PVNS, who were not amenable to surgical treatment with RG7155, a monoclonal antibody that potently inhibits the dimerization of CSF1R.
PET of Somatostatin Receptor–Positive Tumors Using 64Cu- and 68Ga-Somatostatin Antagonists: The Chelate Makes the Difference
TLDR
A report on the development and evaluation of four 64Cu or 68Ga radioantagonists for PET of sst2-positive tumors demonstrates the strong dependence of the affinity and pharmacokinetics of the somatostatin-based radioantagonist on the chelator and radiometal.
Isolation and characterization of antioxidant and antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome.
TLDR
The chloroform extract of mango ginger rhizome was subjected to antioxidant activity-guided purification by repeated silica gel column chromatography to obtain a pure antioxidant compound, which showed antibacterial activity against both Gram-positive and Gram-negative bacteria tested.
89Zr-Lumretuzumab PET Imaging before and during HER3 Antibody Lumretuzumab Treatment in Patients with Solid Tumors
TLDR
PET imaging showed biodistribution and tumor-specific 89Zr-lumretuzumab uptake and there was no clear evidence of tumor saturation by PET imaging as the tumor SUV did not plateau with increasing doses.
ImmunoPET and biodistribution with human epidermal growth factor receptor 3 targeting antibody 89Zr-RG7116
TLDR
PET imaging with this tracer provides real-time non-invasive information about RG7116 distribution, tumor targeting and tumor HER3 expression levels and specifically accumulates in HER3 expressing tumors.
Phase I study of RG7155, a novel anti-CSF1R antibody, in patients with advanced/metastatic solid tumors.
TLDR
Tumor associated macrophages suppress anti-tumor immunity and have been associated with poor prognosis in several types of cancer, and CSF-1 is a critical survival and differentiating agent in these patients.
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