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Glutamic Acid-rich Proteins of Rod Photoreceptors Are Natively Unfolded*
The outer segment of vertebrate photoreceptors is a specialized compartment that hosts all the signaling components required for visual transduction. Specific to rod photoreceptors is an unusual setExpand
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Regulation of the expression of mouse TAP-associated glycoprotein (tapasin) by cytokines.
The expression of antigen presenting MHC class I molecules can be enhanced through cytokines, e.g. upon infection with bacteria or viruses, either directly by enhancing class I gene transcription orExpand
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Bimane Fluorescence Scanning Suggests Secondary Structure near the S3-S4 Linker of BK Channels*
Gating of large conductance Ca2+-activated K+ channels (BK or maxi-K channels) is controlled by a Ca2+-sensor, formed by the channel cytoplasmic C-terminal domain, and a voltage sensor, formed by itsExpand
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Molecular Architecture and Divalent Cation Activation of TvoK, a Prokaryotic Potassium Channel*
RCK (regulator of conductance of potassium) domains form a family of ligand-binding domains found in many prokaryotic K+ channels and transport proteins. Although many RCK domains contain an apparentExpand
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Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain
Regulator of K+ conductance (RCK) domains control the activity of a variety of K+ transporters and channels, including the human large conductance Ca2+-activated K+ channel that is important forExpand
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Allosteric mechanism of Ca2+ activation and H+-inhibited gating of the MthK K+ channel
MthK is a Ca2+-gated K+ channel whose activity is inhibited by cytoplasmic H+. To determine possible mechanisms underlying the channel’s proton sensitivity and the relation between H+ inhibition andExpand
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Binding of Ca2+ to glutamic acid-rich polypeptides from the rod outer segment.
Rod photoreceptors contain three different glutamic acid-rich proteins (GARPs) that have been proposed to control the propagation of Ca(2+) from the site of its entry at the cyclic nucleotide-gatedExpand
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Identification of Divalent Cation Coordinating Residues in a K+ Channel RCK Domain by NMR Spectroscopy
TvoK is a prokaryotic K+ channel whose gating is modulated by divalent cation-binding to a carboxy-terminal RCK domain. To gain insight toward mechanisms underlying divalent cation binding andExpand
§ ZentrumfurBiologischeMagnetischeResonanz/InstitutfurOrganischeChemieundBiochemie,J. W.Goethe-Universitat Frankfurt,Marie-Curie-Strasse11,60439Frankfurt,andInstitutfurBiophysik,J.
The outer segment of vertebrate photoreceptors is a specialized compartment that hosts all the signaling components required for visual transduction. Specific to rod photoreceptors is an unusual setExpand
Multiple Ca2+ Binding Sites in the RCK Domain Contribute to Gating in the MthK K+ Channel
MthK is a prokaryotic Ca2+-gated K+ channel that has yielded structural insight toward mechanisms of RCK domain controlled channel gating. In MthK, a “gating ring” of eight RCK domains regulatesExpand