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Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy
- M. Sendtner, H. Schmalbruch, K. A. Stöckli, P. Carroll, G. Kreutzberg, H. Thoenen
- 6 August 1992
CNTF greatly reduces all the functional and morphological changes in pmn/pmn mice, an autosomal recessive mutant leading to progressive caudo-cranial motor neuron degeneration, and gives new perspectives for the treatment of human degenerative motor neuron diseases with CNTF.
Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration
It is demonstrated that the CNTF mRNA and protein levels and the manner in which they are regulated are compatible with such a function in lesioned peripheral neurons in the adult peripheral nervous system.
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
The complementary DNA-deduced amino-acid sequence and subsequent expression of cDNA clones covering the entire coding region in HeLa-cells indicate that CNTF is a cytosolic protein, and shows thatCNTF is not a target-derived neurotrophic factor.
Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
It is demonstrated that the time course of the expression ofCNTF-mRNA and protein in the rat optic nerve is compatible with such a glial differentiation function of CNTF in vivo, and it is shown that the type 2 astrocyte-inducing activity previously demonstrated in optic nerve extract can be precipitated by an antiserum against CNTF.
Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival
- M. Sendtner, Y. Arakawa, K. A. Stöckli, G. Kreutzberg, H. Thoenen
- BiologyJournal of Cell Science
- 1 February 1991
Summary We have demonstrated that the extensive degeneration of motoneurons in the rat facial nucleus after transection of the facial nerve in newborn rats can be prevented by local ciliary…
The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease ‘Wobbler’ of the Mouse
- K. Kaupmann, M. Sendtner, K. A. Stöckli, H. Jockusch
- BiologyThe European journal of neuroscience
- 1 November 1991
Cntf is not linked to wr, and the expression of CNTF mRNA and protein appears close to normal in facial and sciatic nerves of affected (wr/wr) mice, suggesting that motoneuron degeneration of wobbler mice has its origin in defects other than reduced CNTF expression.
Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations
More on motor neurons
SHORT COMMUNICATION The Gene for Ciliary, Neurotrophic F,actor (CNTF) Maps
Cntf is notlink9d to wr, and the expression of CNTF mRNA and protein appears close to normal in facial and sciatic nerves, of affected mice, suggesting that motoneuron degeneration of wobbler mice has its origin in defects other than r~uced CNTF expression.
RegionalDistribution,Developmental Changes, and Cellular LocalizationofCNTF-mRNA and ProteinintheRat Brain
It is demonstrated that the time course of the expression of CNTF-mRNA andprotein: in the rat op-tic nerve is evaluated by quantitative Northernblotanalysis and biological activity, respectively.