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Identification of an arylalkylamine N‐acyltransferase from Drosophila melanogaster that catalyzes the formation of long‐chain N‐acylserotonins
TLDR
Identification of endogenous amounts of N‐acylserotonins and colocalization of these fatty acid amides and AANATL2 transcripts gives supporting evidence that AANatL2 has a role in the biosynthetic formation of these important cell signalling lipids. Expand
Drosophila melanogaster as a model system to study long‐chain fatty acid amide metabolism
TLDR
It is demonstrated that Drosophila melanogaster is an excellent model system for the study long‐chain fatty acid amide metabolism as it is quantified the endogenous levels of N‐acylglycines, N‐ACYldopamines, N-acylethanolamines, and primary fatty Acid amides by LC/QTOF‐MS. Expand
Mechanistic and Structural Analysis of Drosophila melanogaster Arylalkylamine N-Acetyltransferases
TLDR
A combination of pH–activity profiling and site-directed mutagenesis to study prospective residues believed to function in AANATA catalysis led to an assignment of Glu-47 as the general base in catalysis with an apparent pKa of 7.0. Expand
Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells1[S]
Primary fatty acid amides (PFAM) are important signaling molecules in the mammalian nervous system, binding to many drug receptors and demonstrating control over sleep, locomotion, angiogenesis, andExpand
C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
TLDR
It is shown that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets, which is fundamentally different from the canonical p53 regulation through protein–protein interactions or posttranslational modifications. Expand
CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress*
TLDR
It is shown that by direct transcriptional activation of CerS6, p53 can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response. Expand
In vivo effects of stromelysin on the composition and physical properties of rabbit articular cartilage in the presence and absence of a synthetic inhibitor.
TLDR
Systemic administration of L-696,418 significantly decreased loss of PG from cartilage and prevented the highly localized tissue degradation and the resultant changes in electromechanical behavior caused by intraarticular SLN injection. Expand
Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and
TLDR
A chemical mechanism for AANATL7 is proposed and functions for other important amino acid residues involved in substrate binding and regulation of catalysis are defined and defined. Expand
Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells[S]
TLDR
Heavy-labeled precursor and subtraction lipidomic experiments in mouse neuroblastoma N18TG2 cells, a model cell line for the study of fatty acid amide metabolism, establish the biosynthetic pathways for the N-acylglycines and the PFAMs. Expand
Cartilage degradation and associated changes in biochemical and electromechanical properties.
TLDR
It seems likely that the enzymatic component of OA involves a cascade of activities which work in tandem to degrade the tissue. Expand
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