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The major inflammatory mediator interleukin-6 and obesity
Adipose tissue is one of the main sources of inflammatory mediators, with interleukin-6 (IL-6) among them. Although high systemic levels of inflammatory mediators are cachectogenic and/or anorexic,Expand
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Oxidized fat induces oxidative stress but has no effect on NF-κB-mediated proinflammatory gene transcription in porcine intestinal epithelial cells
Abstract.Objective and design:The effect of oxidized frying oils on PPARγ which is a potent inhibitor of inflammatory responses in the intestine is currently unknown. Thus, the present study aimed toExpand
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Cholestasis predisposes to hypersensitivity to LPS, leading to potential septic complications. We set out to characterize the involvement of Kupffer cell (KC) activation in the hepaticExpand
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The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats
BackgroundDiabetic patients have an increased risk of developing cardiovascular diseases, which are the leading cause of death in developed countries. Although multivitamin products are widely usedExpand
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Effects of Glucocorticoid Agonist and Antagonist on the Pathogenesis of l-Arginine-Induced Acute Pancreatitis in Rat
Objectives: To investigate the consequences of treatment with an exogenous glucocorticoid agonist (methylprednisolone) and antagonist (RU-38486) on the local and systemic responses inExpand
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Supplementation with l-carnitine downregulates genes of the ubiquitin proteasome system in the skeletal muscle and liver of piglets.
Supplementation of carnitine has been shown to improve performance characteristics such as protein accretion in growing pigs. The molecular mechanisms underlying this phenomenon are largely unknown.Expand
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Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats
BackgroundThere is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients areExpand
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Transcriptome profile of the murine macrophage cell response to Candida parapsilosis.
Candida parapsilosis is a human fungal pathogen with increasing global significance. Understanding how macrophages respond to C. parapsilosis at the molecular level will facilitate the development ofExpand
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Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light in recurrent childhood respiratory disease
ObjectivesThe clinical and molecular effects of whole-body polarized light treatment on children suffering from recurrent respiratory infection were studied.MethodsThe incidence and duration ofExpand
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