K Weinhold

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Individuals repeatedly exposed to HIV, but who remain uninfected, form a population enriched for persons likely to have either natural or acquired resistance to the virus. We have studied four such exposed uninfected cohorts, representing 60 individuals, for evidence of protective immunity. This population included participants exposed to HIV through anal(More)
Peripheral blood mononuclear cells (PBMC) of human immunodeficiency virus (HIV)-infected children, age-matched HIV-seronegative controls, and HIV-infected asymptomatic and symptomatic adults were compared for their ability to mediate antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell-mediated cytotoxicity against target cells(More)
Address: 1DHVI and Surgery, Duke University Medical School, Durham, USA, 2ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA, 3Immunology Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA, 4Duke University Medical Center; DHVI and Surgery, Durham, NC, USA, 5University of Alabama, Department of Medicine,(More)
Open Access Oral presentation OA06-04. The role of early T-cell responses in subjects with acute HIV-1 infection MK Liu*1, G Ferrari2, J Salazar3, B Keele3, RL Tanner1, P Hraber4, E Giorgi4, VV Ganusov4, GH Learn4, MG Salazar3, SR Moore1, K Digleria1, Z Yu1, T Rostron1, C DeBoer5, A Williams5, C Margaret5, J Kopycinski6, SL Campion1, VE Bourne1, S(More)
Methods PBMC from 23 acutely infected HIV patients were stimulated with pools of overlapping peptides encompassing all HIV open reading frames. A panel of antibodies directed against cell surface and intracellular entities was employed to stain for HIV-specific CD8 T cells by flow cytometry. Functionality was assessed by the ability to upregulate perforin,(More)
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