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The action of riluzole, a neuroprotective drug, on cloned delayed rectifier K+ channels (Kv1.5 and Kv3.1) was examined using the whole-cell patch-clamp technique. Riluzole reversibly inhibited Kv1.5 currents in a concentration-dependent manner with an IC50 of 39.69+/-2.37 microM. G-protein inhibitors (pertussis toxin and GDPbetaS) did not prevent this(More)
OBJECTIVE To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl. CASE SUMMARY A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion,(More)
Tuberculosis of the head and neck can involve the cervical lymph nodes, larynx, temporal bone, sinonasal cavity, eye, pharynx, thyroid gland, and skull base. Although computed tomography (CT) and magnetic resonance (MR) imaging can accurately demonstrate the sites, pattern, and extent of the disease, both modalities have limitations in the evaluation of(More)
The neurological system plays an important role in modulating some inflammatory skin diseases. Neuro-cutaneous interactions may be mediated by the release of neuropeptides such as substance P (SP) which activate immunocompetent cells in the skin by binding to high affinity neurokinin receptors (NKR). Since epidermal keratinocytes produce a variety of(More)
A 28-year-old woman presented with a recurrent nodule on the lower margin of her left nostril after laser surgery. Histologically, the nodule had an indistinct margin and was composed of interlacing fascicles of plump, spindled or stellate tumor cells with mild cytologic atypia. The tumor cells were revealed to be myofibroblasts by positivity to smooth(More)
The common clinical presentations of herpes simplex virus (HSV) and molluscum contagiosum (MC) are well known to dermatologists. However, folliculitis due to these viruses is an infrequently reported entity and might be considered a sign of immunosuppression [such as infection with human immunodeficiency virus, (HIV)], especially in cases of folliculitis(More)
BACKGROUND AND PURPOSE KD is a rare chronic inflammatory disorder of unknown etiology. The purpose of this study was to evaluate the CT and MR imaging findings of KD in the head and neck. MATERIALS AND METHODS We retrospectively reviewed the CT (n = 21) and MR (n = 9) images obtained in 28 patients (24 males and 4 females; mean age, 32 years; age range,(More)
treatment with diphencyprone. Z Hautkr 1984; 59: 1080 ± 1083. 3. Weisshaar E, Neumann H-J, Gollnick H. Successful treatment of disseminated facial verrucae with contact immunotherapy. Eur J Dermatol 1998; 8: 488 ± 491. 4. Greenberg JH, Smith TL, Katz RM. Verrucae vulgares rejection. A preliminary study on contact dermatitis and cellular immune response.(More)
BACKGROUND Atopic dermatitis is a chronically relapsing, common inflammatory skin disease, which significantly affects quality of life negatively in many respects. Topical steroids are the mainstay of atopic dermatitis treatment but they carry the risk of local side effects. A topical formulation of tacrolimus, a macrolide calcineurin inhibitor, has(More)
BACKGROUND Hemangiomas of the nasal tip, the so-called Cyrano nose, are often deep, disfiguring, and persistent. OBJECTIVE To evaluate the effect of treatment with pulsed dye laser on Cyrano nose. METHODS A 3-month-old boy with hemangioma of the nasal tip of 1-months duration underwent six sessions of pulsed dye laser treatment with a 7 mm collimated(More)