K W Baumann

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In normal dogs, bolus administration of a very high dose of mannitol (2 gm/kg) resulted in a small, transient increase in cerebral blood flow (CBF) of approximately 8 percent lasting less than 10 minutes followed by a significant reduction in CBF of approximately 20 percent lasting at least three hours. The increase in CBF may in part be related to changes(More)
Gammahydroxybutyric acid has been proposed as an alternative to high-dose barbiturate therapy for protecting the brain after ischemic or traumatic insult. The cerebral and systemic metabolic and vascular effects of gammahydroxybutyrate and its lactone analogue, gammabutyrolactone, are addressed in this paper. In anesthetized normal dogs,(More)
In normal dogs, the continuous infusion of 2 g of mannitol per kg resulted in a transient increase in cerebral blood flow of approximately 30%, which was accompanied by a concomitant reduction in cerebrovascular resistance. These changes were maximal 30 minutes after the infusion was initiated and resolved by 180 minutes. The changes were not related to(More)
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