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When administered in a low dose (0.1 mg/kg) the main pineal hormone melatonin decreased the locomotor activity and exploratory behavior of rats in the open field both during the light and dark phases of the day. High doses (1.0 and 10.0 mg/kg) were effective only at night hours (01.00-03.00). After administration of 0.1 mg/kg of melatonin no changes in the… (More)