K. V. N. Poleswara Rao

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Introduction: Diabetes is a risk factor for erectile dysfunction (ED). The proposed mechanisms responsible fordiabetic ED are associated with an increase in reactive oxygen species (ROS) production, over activity of RhoA/ ROCK signaling pathway and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, as seen in experimental models of diabetic rats.(More)
Testosterone is overwhelmingly important in regulating erectile physiology. However, the associated molecular mechanisms are poorly understood. The purpose of this study was to explore the effects and mechanisms of testosterone in erectile dysfunction (ED) in castrated rats. Forty male Sprague-Dawley rats were randomized to four groups (control,(More)
Our previous studies have demonstrated that erectile function was preserved in aged transgenic rats (TGR) harboring the human tissue kallikrein 1 (hKLK1), while the molecular level of hKLK1 on corporal fibrosis to inhibit age-related erectile dysfunction (ED) is poorly understood. Male wild-type Sprague-Dawley rats (WTR) and TGR harboring the hKLK1 gene(More)
Our previous studies had reported that Human Tissue Kallikrein 1 (hKLK1) preserved erectile function in aged transgenic rats, while the detailed mechanism of hKLK1 protecting erectile function in aged rats through activation of cGMP and cAMP was not mentioned. To explore the latent mechanism, male wild-type Sprague-Dawley rats (WTR) and transgenic rats(More)
A meta-analysis was performed to evaluate the efficacy of local anesthesia in alleviating pain during prostate biopsy. We searched relevant articles in PubMed and Embase. The included studies should be randomized controlled trials (RCT) using local anesthesia to alleviate pain during biopsy, which was recorded by a pain scale. Analgesic efficacy of(More)
Objective: The introduction of nerve-sparing radical prostatectomy represents a milestone in the treatment of prostate cancer. However, a certain percentage of cancer survivors still suffer from erectile dysfunction. Recent research has stated that using PDE 5-inhibitors after radical prostatectomy may lead to biochemical recurrence. This study was(More)
Analysis of altered microRNA expression profile in calcium oxalate stone formation. Objective: We investigated the protective effects of the herbal formulation in androgen-deprived rat bladder. Methods: Male rats aged 8 weeks were randomly divided (n=8 in each): sham operation only (normal control), androgen-deprived only (androgen-deprived control),(More)
(TGDMH). CC tissues from all rats were collected in liquid nitrogen or embedded in paraffin. Western blot was used to detect the protein level of transforming growth factor β1 (TGF-β1), smad2/3, phospho-smad2/3, collagen I and collagen IV in CC. Immunohistochemical staining and masson's trichrome staining were conducted to detect the expression of TGF-β1,(More)
Objective: PDE5 inhibitors represent the first line therapy for treatment of ED. However, diabetic patients have poorer response compared with normal patients. The aim of this study was to determine whether taurine, a sulfur-containing amino acid, affects diabetic erectile dysfunction. Methods: Type 1 diabetes mellitus was induced in male rats by(More)
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