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1. The A type of acetylcholine response of Helix neurons is downmodulated by low concentrations of GABA that do not elicit any measurable change in membrane potential or conductance. 2. We find that these physiological actions are associated with an increase in both intracellular cyclic AMP levels and 45Ca2+ influx. 3. The modulation of the acetylcholine(More)
The effect of alpha-bungarotoxin (alpha-BT) on two types of acetylcholine (ACh)-induced currents distinguished by their desensitization properties was studied on the isolated dialyzed Helix neurons by a concentration clamp method. It was shown that alpha-BT depressed both types of ACh responses and this action was reversible in the majority of experiments.(More)
It has been shown that concanavaline A (Co A) inhibited those acetylcholine (ACh) and gamma-aminobutyric acid (GABA) responses of the membrane of dialyzed snail neurons which were blocked by ouabain. The inhibitory effect of Co A on these responses was removed at 5 degrees C. Co A had no significant influence on ACh responses which were insensitive to(More)
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