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Axonal regeneration at a site of peripheral nerve repair can be impeded by the formation of scar tissue, which creates a mechanical barrier and initiates the development of multiple branched axonal sprouts that form a neuroma. We have investigated the hypothesis that the application of a scar-reducing agent to the nerve repair site would permit better(More)
The high incidence of lingual sensory disturbance following lower third molar removal in the UK may be due to the elevation of a lingual flap and insertion of a Howarth's periosteal elevator, in an attempt to protect the lingual nerve. We have therefore studied the validity of this technique by recording the incidence of temporary and permanent lingual(More)
Restorative dental materials and oral health care products come into direct contact with oral mucosa and can cause adverse reactions. In order to obtain an accurate risk assessment, the in vitro test model must reflect the clinical situation as closely as possible. The aim of this study was to develop and optimize a three-dimensional full-thickness(More)
We have investigated the effect of scarring at a site of peripheral nerve repair by comparing regeneration of the sciatic nerve in normal mice and two transgenic strains with an increased or decreased propensity for scarring. The outcome was assessed by quantifying collagen at the repair site, recording compound action potentials and counting myelinated(More)
Scar formation at a site of nerve injury can cause a mechanical barrier to axonal regeneration and lead to the development of multiple axonal sprouts to form a neuroma. We have investigated the hypothesis that the application of a scar-preventing agent to a nerve repair site would enhance regeneration of the nerve and reduce neuroma formation. The left(More)
We previously showed in laboratory studies that the most effective method for repair of damaged lingual nerves was by excision of the neuroma, mobilization of the stumps, and direct reapposition with epineurial sutures. We have now undertaken a prospective study in a series of 53 patients treated by this method and have evaluated the outcome by quantifying(More)
Injury to a branch of the trigeminal nerve may lead to the development of chronic pain in the affected area. The etiology of this condition is not clear, but there is strong evidence to suggest that spontaneous and mechanically induced neural discharge from the injury site plays a crucial role. In laboratory studies, we have characterized this discharge(More)
The buccal nerve may be damaged during surgical procedures which require an incision along the external oblique ridge of the mandible and this study was undertaken to clarify its surgical anatomy. The course and relationships of the nerve were determined in 20 formalin-fixed cadaver specimens. The number of major branches of the nerve ranged from 4 to 8 and(More)
The morphological changes were examined proximal and distal to crush and transection injuries of the lingual/chorda tympani nerve. Under general anaesthesia the nerve was transected unilaterally in 6 adult cats and crushed with watchmakers forceps in 6 others. After 12 wk, again under general anaesthesia, the injured and contralateral (control) nerves were(More)
The characteristics of regenerated fibres in the chorda tympani have been investigated in cats after nerve section without repair or after section followed by nerve repair twelve weeks later. In the unrepaired group the animals were allowed to recover for twenty four weeks and after delayed repair there was a further recovery period of twelve or twenty four(More)