Learn More
Amphetamine and tranylcypromine are structurally related chemical isomers with pharmacologically distinctive activity profiles. Since they are equimolar and structurally similar they may be used to assess the pharmacologically distinctive activity profiles. Since they are equimolar and structurally similar they may be used to assess the pharmacological(More)
1. Adult male outbred albino mice were acutely injected with either of two dopamine (DA) agonists; Apomorphine, a receptor agonist, or Amantadine, a DA releasing agent. 2. Both drugs produced dose-related alterations in initial Y-maze behavior, consisting of significantly increased proportions of 2-arm entries. 3. This behavior has previously been shown to(More)
In the first experiment, adult male Swiss-Webster mice were systemically injected with a standard dose of morphine. Compared to the influence of vehicle, the motor activity of morphine-injected mice was increased. Neither phenytoin sodium nor carbamazepine alone facilitated motor activity, but pretreatment with both drugs further facilitated the increased(More)
Morphine and related opioid compounds are known to possess proconvulsant activity based upon both electroencephalographic and behavioral criteria. The present authors previously suggested that opiate-related seizures were behaviorally inhibitory, and this was further investigated in the present study. The effects of pretreatment with three pharmacologically(More)
The effects of morphine and an enkephalin analog on murine Y-maze behavior were examined. Vehicle-treated groups primarily showed an alternation response, entering the least recently visited alley of the maze. Treatment with morphine or the analog caused significantly reduced alternation, i.e., arms were entered with equal probability. Naloxone alone had no(More)
Adult male Swiss-Webster mice of varying group size (single, or in groups of 2, 3, or 4) were injected with vehicle, or 2.5 or .50mg/lcg of morphine sulfate. In comparison with vehicle, morphine-injected mice showed heightened behavioral activity consisting mainly of stereotyped forward locomo-tion. This motor response was disproportionately enhanced by the(More)
Previous studies have suggested that aversive and stressful stimulation may affect endogenous opioid systems and produce physiological changes (e.g., analgesia, Straub tail response) typically associated with opiate stimulation. The present experiment addressed the effect of stressful but not immediately painful stimulation upon an opiate-mediated syndrome(More)
Group-housed adult male Sprague-Dawley rats were given a series of 4 exposures to electroconvulsive shock therapy or equivalent handling without shock (sham treatment). Twenty-four hours after the final treatment the rats were given vehicle or one of two doses of morphine intraperitoneally, and motor activity was assessed by remote sensing for 60 min. A(More)
We have previously demonstrated that adult male Sprague-Dawley rats which are chronically maintained upon a schedule of intracranial reward (ICS) show elevated rates of response after a mild tail pinch. Both dopamine and opiates have been implicated in the mediation of other stress induced behavioral alterations, and may therefore also possibly be involved(More)
  • 1