K. R. K. Sateesh

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The aim of the present study is to evaluate the quantitative contribution of passive permeability to P-glycoprotein-mediated (P-gp-mediated) efflux and the functional activity of P-gp in determining intestinal absorption of drugs, and demonstrate the relationship between efflux parameters and intestinal permeability. MDRI-MDCKII cell monolayer permeability,(More)
Worldwide, tuberculosis (TB) remains one of the most important communicable diseases in terms of morbidity and mortality. Its control requires multi-drug therapy for at least six months, which could lead to patient non-compliance, failure of therapy and ultimately resulting in the emergence of drug resistance. Fixed dose combinations (FDCs) in TB therapy(More)
The paper presents two atypical risk chain prediction metrics for barometer coupling and accord in software systems. Our aboriginal metric, Ideal Coupling between Object classes (ICBO), is based on the acclaimed CBO coupling metric, while the added metric, Ideal Lack of Cohesion on Methods (ILCOM5), is based on the LCOM5 accord metric. One advantage of the(More)
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