K. Nakata

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We have previously developed a general method based on the statistical technique of discriminant analysis to predict splice junctions in eukaryotic mRNA sequences [Nakata, K., Kanehisa, M. and DeLisi, C. (1985) Nucleic Acids Res., 13, 5327-5340]. In order to evaluate further applicability of this method, we now analyze the promoter region of Escherichia(More)
Matrices are often required to be well-conditioned in a wide variety of areas including signal processing. Problems to find the nearest positive definite matrix or the nearest correlation matrix that simultaneously satisfy the condition number constraint and sign constraints are presented in this paper. Both problems can be regarded as those to find a(More)
OBJECTIVE Excessive mechanical stress on synovial joints causes osteoarthritis (OA) and results in the production of prostaglandin E2 (PGE2), a key molecule in arthritis, by synovial fibroblasts. However, the relationship between arthritis-related molecules and mechanical stress is still unclear. The purpose of this study was to examine the synovial(More)
  • B. Mandelbaum, H. Roos, M.S. Shive, K. Hambly, K. Mithoefer, S. Della Villa +97 others
  • 2009
The soccer athlete has a greater incidence of overuse and acute knee injuries and as a consequence is at most risk for chondropenia and osteoarthritis. Chondropenia conceptually defines the complex nature of the multivariable processes over time including acute and chronic injury, modulators and the aging process. The role of the Sports Medicine team is to(More)
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