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We evaluated a 35-year-old diabetic male patient with type A insulin resistance, showing acanthosis nigricans. Insulin binding to the patient's Epstein-Barr-virus transformed lymphocytes was mildly reduced. The maximal insulin-stimulated autophosphorylation of the insulin receptor from the patient's transformed lymphocytes was decreased to 45% of that from(More)
We developed a method for multiple alignment of protein sequences. The main feature of this method is that it takes the evolutionary relationships of the proteins in question into account repeatedly for execution, until the relationships and alignment results are in agreement. We then applied this method to the data of the international DNA sequence(More)
The suppressing effect of the hot-water extract of Cassia nomame (Sieb.) HONDA was studied on the frequency of chromosomal aberrations in Chinese hamster ovary K1 (CHO-K1) cells. CHO-K1 cells were pretreated with 2.5 microM Mitomycin C (MMC) for 1 h and incubated with or without the extract in medium for 10-24 h. The frequency of chromosome aberrations in(More)
According to the 45 nm BEOL technology node, we demonstrated that a homogeneous interlayer dielectric with dielectric constant of 2.25 has a substantial advantage in terms of RC delay reduction compared to other potential architectures such as hybrid and tri-level dielectrics. Combination of the homogeneous interlayer dielectric and ultra-thinned barrier(More)
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