K. Mukaida

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BACKGROUND Microdialysis studies have demonstrated that the release of serotonin (5-hydroxytryptamine, 5-HT) in the serotonergic projection areas increases during waking and decreases during sleep in rat and cat, suggesting that 5-HT plays an important role in modulation of sleep. Although it might be expected that 5-HT release is also decreased during(More)
—Cryptography circuits for smart cards and portable electronic devices provide user authentication and secure data communication. These circuits should, in general, occupy small chip area, consume low power, handle several cryptography algorithms , and provide acceptable performance. This paper presents, for the first time, a hardware implementation of(More)
The mechanism of the antinociceptive action of nitrous oxide (N(2)O) is not fully understood. It was reported that N(2)O induces opioid peptide release in the rat midbrain, which can activate the descending inhibitory system in the spinal cord. Although effects of N(2)O on the noradrenergic descending inhibitory system have been established, effects of(More)
BACKGROUND The mechanism of the antinociceptive effects of nitrous oxide (N(2)O) has not been completely elucidated. On the other hand, numerous studies have indicated that mesolimbic dopaminergic neurons, which are thought to be involved in rewarding and reinforcement processes, play important roles in the supraspinal pain-suppression system. We(More)
Higher birth order is associated with a smaller risk of allergy (birth order effect). The purpose of this study was to compare the significance of the birth order effect on the prevalence of specific allergic diseases [bronchial asthma (BA), atopic dermatitis (AD), allergic rhinitis (AR), allergic conjunctivitis (AC), and food allergy (FA)] among(More)
BACKGROUND Nociceptin is the endogenous agonist of the opioid receptor-like (ORL) 1 receptor (NOP), and both nociceptin and NOP are widely expressed in the brain and spinal cord, which are target organs of general anaesthetics. As nociceptin has been reported to be involved in modulating pain mechanisms and stress responses, it is possible that the activity(More)
Some genetic studies have shown a linkage between malignant hyperthermia susceptibility (MHS) and chromosome 19q or the skeletal muscle ryanodine receptor (RYR1) gene. Some types of MHS seem to be caused by an abnormality of calcium-induced calcium release (CICR). We analyzed the linkage of RYR1 gene polymorphisms in Japanese MHS families and investigated(More)
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