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Four different mutations of the cytochrome P450 CYP2D6 gene associated with the poor metabolizer phenotype (PM) of the debrisoquine/sparteine polymorphism were analyzed by Xba I restriction fragment length polymorphism (RFLP) analysis and a polymerase chain reaction (PCR)-based DNA amplification method in DNA of 394 healthy European subjects; 341 of these(More)
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcriptional regulator of several genes including the cytochrome P4501 (CYP1) family as well as genes encoding factors involved in cell growth and differentiation. In mice, several polymorphic forms of the AHR are known, some of which have altered affinity for toxic and carcinogenic ligands.(More)
  • Kai Brügge, D. Hildebranda, +12 authors A. Wilbertd
  • 2016
K. A. Brügge b∗, M. L. Ahnena, M. Balboc, M. Bergmannd , A. Bilanda, C. Bockermanne, T. Bretza, J. Bussb, D. Dornerd , S. Eineckeb, J. Freiwaldb, C. Hempflingd , D. Hildebranda, G. Hughesa, W. Lustermanna, K. Mannheimd , K. Meierd , K. Morike, S. Müllera, D. Neisea, A. Neronovc, M. Nötheb, A.-K. Overkempingb, A. Paravacd , F. Paussa, W. Rhodeb, F. Temmeb,(More)
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