Learn More
Hormones may produce long-term effects on excitability by regulating K+ channel gene expression. Previous studies demonstrated that administration of dexamethasone, a glucocorticoid receptor agonist, to adrenalectomized rats, rapidly induces Kv1.5 K+ channel expression in the ventricle of the hear. Here, RNase protection assays and Northern blots are used(More)
Auditory evoked responses recorded from the CA3 region of the rat hippocampus show diminished response to repeated stimuli, suggesting the activity of an inhibitory gating mechanism. The effects on this putative gating mechanism of two GABAB receptor antagonists, CGP35348 and CGP46381, were characterized in a conditioning testing paradigm. Both compounds,(More)
  • 1