K M Francis-Thickpenny

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Epithelial ovarian carcinoma is often diagnosed at an advanced stage of disease and is the leading cause of death from gynaecological neoplasia. The genetic changes that occur during the development of this carcinoma are poorly understood. It has been proposed that IGFIIR, TGFbeta1 and TGFbetaRII act as a functional unit in the TGFbeta growth inhibitory(More)
cancer is often diagnosed at advanced stages of the disease. Despite improvements in chemotherapy and surgical treatment, the overall 5-year survival rate for patients with epithe-lial ovarian cancer remains at only 35% (Landis et al, 1998). Overall, the molecular changes that underlie the initiation and development of this tumour are poorly understood. A(More)
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