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Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers multidrug resistance to tumor cells. Modulators of multidrug resistance block the action of these pumps, thereby sensitizing cells to oncolytics. A potent Pgp modulator is LY335979, which fully sensitizes Pgp-expressing cells at(More)
It is widely believed that antigen heterogeneity and noninternalization of antigen-antibody complexes will severely limit the antitumor activity of monoclonal antibody-drug conjugates. The B72.3 monoclonal antibody binds to a tumor-associated antigen which is heterogeneously expressed in human carcinomas (We therefore performed studies to assess the degree(More)
In this paper, bit interleaved coded modulation with the mapping of different delayed codewords onto the same signals is investigated. This scheme is referred to as delayed bit interleaved coded modulation (DBICM) and the principles of its coding and decoding are presented. Simulation results show that a coding gain of 0.7 dB and 0.5 dB can been achieved by(More)
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