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An outbreak of acute liver failure occurred at a dialysis center in Caruaru, Brazil (8 degrees 17' S, 35 degrees 58' W), 134 km from Recife, the state capital of Pernambuco. At the clinic, 116 (89%) of 131 patients experienced visual disturbances, nausea, and vomiting after routine hemodialysis treatment on 13-20 February 1996. Subsequently, 100 patients(More)
Extracts of samples of a Caribbean tunicate (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low concentrations the growth of DNA and RNA viruses as well as L1210 leukemic cells. The active compounds isolated from the tunicate, didemnins A, B, and C, are depsipeptides, and didemnin B (a derivative of didemnin A) is the component active at(More)
The hydromedusa Polyorchis penicillatus is a good model system to study neurotransmission in coelenterates. Using a radioimmunoassay for the peptide sequence Arg-Phe-NH2 (RFamide), two peptides have now been purified from acetic acid extracts of this medusa. The structure of one of these peptides was established as pyroGlu-Leu-Leu-Gly-Gly-Arg-Phe-NH2, and(More)
Fast atom bombardment mass spectrometry has become a powerful structural tool since the first reports of its use in 1981. Samples are ionized in the condensed state, usually in a glycerol matrix, by bombarding the matrix with xenon or argon atoms with energies of 5000 to 10,000 electron volts. This yields both positive and negative secondary ions, which are(More)
Cnidarians are the lowest animal group having a nervous system. Using a radioimmunoassay for the C-terminal sequence Arg-Phe-NH2 (RFamide), we have isolated three novel neuropeptides from the jellyfish Cyanea lamarckii (belonging to the class Scyphozoa): (Glu-Trp-Leu-Arg-Gly-Arg-Phe-NH2 (Cyanea-RFamide I), (Glu-Pro-Leu-Trp-Ser-Gly-Arg-Phe-NH2(More)
† " Nature herself must be our advisor; the path she chalks must be our walk. For as long as we confer with our own eyes, and make our ascent from lesser things to higher, we shall be at length received into her closest-secrets. " † " This paper is dedicated to the memory of P J. Scheuer (1916-2003) a pioneer in marine drug research and discoverer of(More)
Structures of the second adipokinetic hormones (AKH II's) from three locust species have been assigned by fast atom bombardment mass spectrometry. The AKH II hormone is identical in two Schistocerca species, S. nitans and S. gregaria, but is different in Locusta migratoria. Both AKH II's are related to red pigment-concentrating hormone (RPCH) from prawns,(More)
Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide), we have isolated the peptide Leu-Pro-Pro-Gly-Pro-Leu-Pro-Arg-Pro-NH2 (Antho-RPamide) from an extract of the sea anemone Anthopleura elegantissima. Antho-RPamide is located in neurons of sea anemones. Application of low concentrations of Antho-RPamide to tentacle preparations of(More)
Two neuropeptides with adipokinetic activity in Locusta migratoria and hypertrehalosaemic activity in Periplaneta americana were purified by high-performance liquid chromatography from the corpus cardiacum of the lubber grasshopper, Romalea microptera. The sequences of both peptides, designated Ro I and Ro II, were determined by gas-phase sequencing(More)
† " Nature herself must be our advisor; the path she chalks must be our walk. For as long as we confer with our own eyes, and make our ascent from lesser things to higher, we shall be at length received into her closest-secrets. " † " This paper is dedicated to the memory of P J. Scheuer (1916-2003) a pioneer in marine drug research and discoverer of(More)