K. Kyriallis

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Tumor necrosis factor-α (TNFα) is a pluripotent proinflammatory cytokine and is thought to play an important role in the inflammatory process of multiple sclerosis (MS). A G→A transition in the TNFα promotor at position –308 (TNF2 allele) has been shown to be associated with increased TNFα production. This study was designed to detect wether the TNF2 allele(More)
A United Nations (UNHCR)-sponsored study has been undertaken, involving neurologists from the Turkish-speaking northern and Greek-speaking southern communities of Cyprus, to ascertain the prevalence of multiple sclerosis (MS) and to bring the medical personnel of the two communities to work together. The Turkish community includes both Turkish Cypriots and,(More)
Familial infantile myasthenia is an autosomal recessive disorder, recently classified as congenital myasthenic syndrome type Ia. Onset of symptoms is at birth to early childhood with significant myasthenic weakness and possible respiratory distress, followed later in life by symptoms of mild to moderate myasthenia. Thirty-six patients of 12 families, seven(More)
OBJECTIVE To identify and to characterize functionally the mutational basis of congenital myasthenic syndromes (CMS) linked to chromosome 17p. BACKGROUND A total of 37 patients belonging to 13 CMS families, 9 of them consanguineous, were investigated. All patients were linked previously to the telomeric region of chromosome 17p. Two candidate genes in(More)
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