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BACKGROUND Valproic acid (VPA) causes the failure of neural tube closure in newborn mice. However, the molecular mechanism of its teratogenesis is unknown. This study was conducted to investigate the genomewide effects of VPA disruption of normal neural tube development in mice. METHODS Microarray analysis was performed on the head part of NMRI mouse(More)
BACKGROUND Valproic acid (VPA) is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its teratogenic mechanisms are unknown. We have attempted to describe a fundamental role of the Polycomb group (Pc-G) in VPA-induced transformations of the axial skeleton. METHODS Pregnant NMRI mice were given a single subcutaneous(More)
A new mouse monoclonal antibody (mAb), HUKT was raised against chicken peripheral blood thrombocytes. The mAb HUKT appeared to detect a specific marker on the surface of chicken thrombocytes. Flow cytometry (FCM) analysis revealed that it did not react with cells from the normal thymus, bursa of Fabricius, six kinds of chicken cell lines, chicken(More)
An experiment comparing programming productivity of Lisp, Prolog, and Ada used in the AI (Artificial Intelligence) area is reported. Lisp and Prolog have been the main languages used for AI programming because of their symbol manipulation and list processing facilities. There is a possibility, however, that general purpose languages such as Ada or C can be(More)