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We report ultrasensitive Ca(2+) indicators, yellow cameleon-Nano (YC-Nano), developed by engineering the Ca(2+)-sensing domain of a genetically encoded Ca(2+) indicator, YC2.60 or YC3.60. Their high Ca(2+) affinities (K(d) = 15-140 nM) and large signal change (1,450%) enabled detection of subtle Ca(2+) transients associated with intercellular signaling(More)
The results of the second phase of the Super-Kamiokande solar neutrino measurement are presented and compared to the first phase. The solar neutrino flux spectrum and time-variation as 2 well as oscillation results are statistically consistent with the first phase and do not show spectral distortion. The time-dependent flux measurement of the combined first(More)
Super-Kamiokande is the world's largest water Cherenkov detector, with net mass 50,000 tons. Earth's atmosphere, and the K2K long-baseline neutrino beam with high efficiency. These data provided crucial information for our current understanding of neutrino oscillations, as well as setting stringent limits on nucleon decay. In this paper, we describe the(More)
SUMMARY A time-interleaved ADC system is an effective way to implement a high-sampling-rate ADC with relatively slow circuits. In the system, several channel ADCs operate at inter-leaved sampling times as if they were effectively a single ADC operating at a much higher sampling rate. Mismatches among channel ADCs degrade SNR and SFDR of the ADC system as a(More)
This paper presents a high-accuracy image matching technique using a phase-only correlation (POC) function. The POC-based image matching enables estimation of image displacements with 1/10~1/100-pixel accuracy by a function fitting technique using the closed-form representation of the POC function's peak. This method requires an iterative process for the(More)