K K Sadanaga

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The protective effect of chlorpromazine on rat spinal cord injury was investigated using a dynamic impact model. A 10 g weight was dropped 5 cm on an impounder placed on the exposed spinal cord at the T-11 level. Changes in potassium concentration on the epidural surface of the injured spinal cord were measured using a combined impounder-K+ electrode(More)
Charybdotoxin, a highly specific inhibitor of calcium-activated potassium efflux, was found to protect rat spinal cord against dynamic impact injury. In a control (nontreated) group, a weight drop of 10 gram X 5 cm on the T-11 segment of the rat spinal cord paralyzed hindlimbs, and recovery was slow. After 4 weeks, Tarlov scores (a behavioral index) were 1(More)
A combined impounder-surface K+ electrode was developed to measure change in K+ ion concentration of the cerebrospinal fluid (CSF) across the dura and arachnoid maters. To determine whether K+ permeability of the rat dura and arachnoid maters is due to an intrinsic permeability, a study was conducted using an atraumatic laminectomy model. Dorsal laminectomy(More)
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