K. J. Schlüter

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Counterregulatory secretion of epinephrine occurs during severe insulin-induced hypoglycemia. Under these conditions (minimal plasma glucose 27.4 +/- 1 mg/dl) the decrease of serum potassium concentration (0.9 mVal/L) is mediated by two mechanisms: insulin-induced (0.48 mVal/L) and epinephrine-induced (0.42 mVal/L) cellular uptake of potassium.(More)
The insulin receptor binding of human and pork insulin was measured in four different pork brain tissues. In medial hypothalamus, infundibulum of pituitary gland, neurohypophysis, and adenohypophysis insulin receptors were found. Binding of mono-125I-(TyrA14)-insulin proceeded rapidly at 37 degrees C, pH 7.4, and reached a steady state for human and pork(More)
The glucose clamp technique was used to compare the biological activity of purified porcine insulin and Biosynthetic Human Insulin (BHI). An intravenous bolus of 0.1 U/kg BW was injected in eight male volunteers, and the glucose was clamped at baseline values (euglycemic clamp). Serum insulin, serum C-peptide and plasma glucose did not differ between(More)
Fully synthetic human insulin (CGP 12'831) was compared to porcine insulin in identical and non-identical formula by intravenous insulin tolerance tests in 12 volunteers. The half-lives of the three insulins tested did not differ (t 1/2: 5.5 +/- 0.2 minutes), though acid porcine insulin exhibited lower serum peak values. The hypoglycemic effects of the(More)
The pharmacokinetics and the endocrine profile of a new low molecular somatostatin derivative, SMS 201-995, were investigated in a group of 35 normal subjects. Clearance studies (n = 6) for this peptide showed a prolonged half-life in plasma, 113 min, following single sc injections of 50 or 100 micrograms. Arginine stimulation tests (n = 6) were conducted(More)
The biologic effect of human insulin (recombinant DNA) and purified pork insulin (PPI) was compared during insulin-induced hypoglycemia at two intravenous dosages 0.075 and 0.1 U/kg body wt in healthy volunteers. Serum insulin concentrations and plasma glucose curves were identical. PPI induced a significantly (P less than 0.05) higher output of(More)
Human insulin (recombinant DNA) and purified porcine insulin were compared in healthy men. Intravenous insulin tolerance tests showed identical effects on plasma glucose when a bolus of 0.1 U/kg was injected. Following human insulin, hypokalemia and epinephrine secretion were significantly less pronounced. The differences in serum potassium concentrations(More)
β-adrenoceptor stimulation in vivo shifts potassium into the cells. To examine whether human erythrocytes participate in this process, we measured, along with serum or plasma potassium, the concentrations of potassium and sodium in erythrocytes. β-adrenoceptor stimulation was obtained by infusion of either fenoterol or hexoprenaline into 6 volunteers at(More)
Simultaneous treatment with antidiabetic drugs and beta-adrenoceptor blocking agents is frequent on account of the high incidence of diabetes and cardiovascular disease. The effects of oral doses of pindolol, metoprolol, and propranolol on the response to insulin-induced hypoglycemia and an oral glucose load were investigated. During hypoglycemia metoprolol(More)
Counterregulatory effect following administration of biosynthetic human proinsulin (BHPI) and human insulin (BHI) were compared during hypoglycemia standardized by means of a glucose controlled insulin infusion system (GCIIS). A total of 0.148 +/- 0.010 U/kg of BHPI had to be given by the GCIIS in order to obtain a minimal blood glucose (BG) of 26 +/- 2(More)