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Long-term potentiation (LTP) was induced in the commissural pathway to CA3 in vivo. Tissue slices were prepared from potentiated and control hippocampi and preloaded with [14C]glutamate ([14C]glu). K+-stimulated release of [14C]glu from these slices was compared in the absence and presence of extracellular Ca2+. High-affinity uptake and Ca2+-independent(More)
In situ hybridization histochemistry in combination with RNA blot techniques was used to study the regulation of opioid gene expression in rat hippocampus. By use of a prodynorphin cDNA probe, a strong hybridization signal was identified in the granule cell layer of the hippocampus. However, experiments using a proenkephalin cDNA probe revealed that the(More)
Long-term potentiation (LTP) in the CA3 hippocampal subfield, elicited in vivo, produced significant increases in basal and in carbachol- and noradrenaline-induced hydrolysis of phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2) as measured by the accumulation of InsP1 in hippocampal slices in vitro. Kindling, however, resulted in significant decreases in(More)
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