K J Feasey

  • Citations Per Year
Learn More
In situ hybridization histochemistry in combination with RNA blot techniques was used to study the regulation of opioid gene expression in rat hippocampus. By use of a prodynorphin cDNA probe, a strong hybridization signal was identified in the granule cell layer of the hippocampus. However, experiments using a proenkephalin cDNA probe revealed that the(More)
Long-term potentiation (LTP) was induced in the commissural pathway to CA3 in vivo. Tissue slices were prepared from potentiated and control hippocampi and preloaded with [14C]glutamate ([14C]glu). K+-stimulated release of [14C]glu from these slices was compared in the absence and presence of extracellular Ca2+. High-affinity uptake and Ca2+-independent(More)
Long-term potentiation (LTP) in the CA3 hippocampal subfield, elicited in vivo, produced significant increases in basal and in carbachol- and noradrenaline-induced hydrolysis of phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2) as measured by the accumulation of InsP1 in hippocampal slices in vitro. Kindling, however, resulted in significant decreases in(More)
  • 1