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The present study was designed to examine whether the left atrium is dilated in paroxysmal atrial fibrillation or not. Left atrial dimension (LAD) on M-mode echocardiogram was (1) 23.3 +/- 0.7 mm (mean +/- S.E.) in 24 normal subjects, (2) 30.5 +/- 0.7 mm in 58 patients without atrial fibrillation who had hypertension and/or ischemic heart disease, (3) 35.5(More)
During the past 10 years we experienced 234 patients with atrial fibrillation of whom 94 patients (40.2%) showed a paroxysmal form. Underlying diseases of these 94 patients were hypertension and/or coronary heart disease in 51 (54.3%), rheumatic valvular disease in 3 (3.2%), hyperthyroidism in 2 (2.1%), and miscellaneous diseases in 15 patients (16.0%).(More)
The relation of plasma levels of atrial natriuretic peptide (ANP) to those of cyclic 3', 5'-guanosine monophosphate (cGMP) was studied in 43 patients with various heart diseases. Plasma levels of both ANP and cGMP were significantly (p less than 0.001) elevated in 34 patients with chronic heart diseases, and a significant positive correlation was observed(More)
We observed elevation of serum CPK in hypertensive patients under pindolol treatment. In this report, we showed a representative patient and compared serum CPK values in 56 patients under pindolol treatment to those in 64 patients under propranolol treatment. Mean serum CPK values in the patients under pindolol treatment and propranolol treatment were 117.0(More)
Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of the myocardial cell damage involved in viral myocarditis. To investigate the cellular and molecular bases of both target cells and effector cells for cell-mediated cytotoxicity involved in viral myocarditis and dilated cardiomyopathy, we first examined the expression of major(More)
The effect of methylprednisolone sodium succinate (MP) on release of myosin light chain II (LCII) from the myocardium was studied in experimental myocardial infarction (MI). Acute MI was produced in conscious, closed-chest dogs by ligating the left anterior descending coronary artery beyond the first diagonal branch. MP, 30 mg/kg, was administered(More)