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A single human cell contains more than 5.0 × 105 copies of long interspersed element-1 (L1), 80–100 of which are competent for retrotransposition (L1-RTP). Recent observations have revealed the presence of de novo L1 insertions in various tumors, but little is known about its mechanism. Here, we found that 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(More)
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